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Release v4.21

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@benguscott benguscott released this 18 Jun 12:14
0b48f8a

First public release. A genomic-report generator that turns raw consumer DNA data into a ~50-page research/educational PDF across 33 domains and 413 annotated SNPs.

Validated

End-to-end on real exports from FTDNA, AncestryDNA (V2.0), 23andMe (v5), and MyHeritage — all GRCh37 — plus the AncestryDNA + MyHeritage dual-dataset merge. .gz inputs are handled transparently.

Not yet supported / untested

VCF is not implemented; LivingDNA is experimental and untested; build-38 files and other platform vintages are unvalidated (see README → Supported Input Formats).

Highlights

  • ROH corrected — terminal runs emitted, autosomes-only scan, and a 1 Mb max-gap split so centromere SNP-deserts no longer inflate F_ROH. (F_ROH values differ from earlier builds — re-baseline if you compare across reports.)
  • Cross-platform robustness — AncestryDNA platform label fixed; §35 key-finding checks made allele-order-insensitive (AncestryDNA reports arbitrary allele order).
  • Safety — a CYP2C9 no-call is no longer reported as a normal warfarin metaboliser.
  • Honesty — report coverage labels disambiguated; supported-format claims corrected.

Not medical advice

Research and informational use only. Confirm any finding with an accredited clinical laboratory. See the disclaimer in README and the per-report disclaimer.