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Design doc for drug combination trials #939

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Design doc for drug combination trials #939

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43c699f
start 2 drugs combo design doc
danielinteractive Mar 10, 2026
2728015
add more details for the combo model definition
danielinteractive Mar 11, 2026
695efac
more thoughts
danielinteractive Mar 11, 2026
09f092d
add more information
danielinteractive Apr 7, 2026
6b62ade
start planning the implementation
danielinteractive Apr 7, 2026
0ba6757
first idea for hierarchical design, now switch to combo with fixed pr…
danielinteractive Apr 7, 2026
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4 changes: 4 additions & 0 deletions design/.gitignore
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*.html
*.pdf
*_files/

/.quarto/
**/*.quarto_ipynb
16 changes: 16 additions & 0 deletions design/references.bib
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@article{Neuenschwander2015,
title={Bayesian industry approach to phase {I} combination trials in oncology},
author={Neuenschwander, Beat and Matano, Alessandro and Tang, Zhongwen and Roychoudhury, Satrajit and Wandel, Simon and Bailey, SA},
journal={Statistical methods in drug combination studies},
pages={95--135},
year={2014},
publisher={CRC Press Boca Raton, FL}
}

@Manual{Schroeter2023,
title = {decider: Decision making in multiple-arm oncology dose escalation trials with logistic regression},
author = {Lukas Schroeter},
year = {2023},
note = {R package version 0.0.0.9012},
url = {https://Boehringer-Ingelheim.github.io/decider/},
}
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